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Nucleofill 25 – Biorestructuring – 1.5ml


A powerful biostimulatory product for rejuvenation of the ageing face, Nucleofill 25 (formerly Strong) is highly concentrated with 2.5% polynucleotides. Its fibroblast-stimulating and antioxidant properties help to increase collagen production, promote dermal hydration & density, reduce wrinkles & scars, and create a skin lifting effect.

This product comes in the form of a pre-filled 1.5ml syringe. Needles not included. Select your preferred quantity below.

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SKU GUS-2430-SKI Categories , , , , All prices are as displayed.


About the Nucleofill range

The Nucleofill range of Eyes, 20, Medium Plus and 25 products by Promoitalia represents a regenerative approach to treatments with a single key active ingredient. Each product in the Nucleofill range is intended for its own facial or scalp application, and each contains its own specific concentration of polymerised polynucleotides. These are powerful free radical fighters that help stimulate fibroblast growth in the epidermis and dermis, as well as hair density in the scalp region. Polynucleotides also possesses strong hydrophilic properties that act as magnets for water molecules, encouraging them to bind to and hydrate the skin. In all, the Nucleofill range can help restore some of the key characteristics of a youthful appearance that are otherwise lost with age.

Nucleofill 25 highlights:

  • Premium-quality, sterile, pyrogen-free regenerative product with 2.5% polynucleotides per 1.5ml
  • pH between 6.8 – 7.5; viscosity 48-65 pa*s
  • Indicated primarily for facial application
  • Suitable for ageing and sun-damaged skin, it promotes overall skin rejuvenation whilst targeting key ageing markers such as wrinkles, skin laxity and atrophic scars
  • Water-biding properties of polynucleotides promote iso-osmotic hydration of the skin in the long term
  • Biorestructuring effect: restores youthful soft tissue turgor, density and volume at a deeper level
  • Improves circulation in the skin and targets deep hyperpigmentation
  • An alternative to dermal fillers and synthetic biostimulators without risk of lumping, distortion or long-term side effects
  • Alternative use: stretch marks on the body and natural improvement of deeper, indented scars
  • Convenient pre-filled product: 1.5ml covers one facial treatment
  • Notes:

    Administration – skin treatment:

    1. Bolus applications into the skin (BAP – bioaesthetic points technique), five points on each side of the face, up to 1.5ml per point;
    2. Frequency: 2-4 sessions spaced from two to four weeks apart
    3. Maintenance: 1 session every 3-6 months.

    One sterile 1.5ml Nucleofill 25 product covers one individual treatment application.

    Results: after the initial treatment and within 5-7 days of application, the skin will look brighter and more rejuvenated. Thereafter, it takes a few weeks for the full effects of the biostimulation process to be realised. The regenerative process continues after the completion of each treatment, ultimately helping to regenerate skin density, with long-lasting improvements visible after a full treatment course is realised.

    Product disclaimer: For information on risks and side effects, read the box’s leaflet insert and ask your doctor or pharmacist. Any advice given acts as a guide only; individual suitability and treatment frequency must be pre-assessed. As body chemistry varies, effectiveness and reactions may also differ. Intended for use by professionals. Do not use on broken skin or in areas of infection. Do not use if hypersensitive to polynucleotides. Consult a qualified practitioner before use in pregnant or breastfeeding women. Store at room temperature. If seal is broken, do not use.

    Additional information

    Weight0.044 kg
    Dimensions18.7 × 7 × 3.3 cm



    2.5%/1.5ml Polynucleotides


    Enclosed in box

    Shelf Life

    2 years from date of manufacture


    1 box (1.5ml syringe)

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    For any injectable, microneedling and/or topical product: we advise that you conduct a patch test and wait in accordance with manufacturer advice (as per the product's packaging and/or enclosed literature) before proceeding to use it. You must agree not to use any products purchased on this website without taking appropriate measures and precautions against any potential harm that may arise. We assume no liability for the negative consequences of self-use.

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