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Nucleofill 20 (Medium) – Hair & Skin – 1.5ml


A versatile biostimulator that can be used for facial and hair rejuvenation, Nucleofill 20 (formerly Medium) is an advanced 2% polynucleotide gel. Its cell renewal and antioxidant effects help to stimulate collagen & fibroblast production, increase dermal density, reduce wrinkles & scars, and promote youthful hair density in the scalp region.

This product comes in the form of a pre-filled 1.5ml syringe. Needles not included. Select your preferred quantity below.

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SKU GUS-2420-SKI Categories , , , , , All prices are as displayed.


About the Nucleofill range

The Nucleofill range of Eyes (formerly Soft Plus), 20 (formerly Medium), Medium Plus and Strong Plus products by Promoitalia represents a regenerative approach to treatments with a single key active ingredient. Each product in the Nucleofill range is intended for its own facial or scalp application, and each contains its own specific concentration of polymerised polynucleotides. These are powerful free radical fighters that help stimulate fibroblast growth in the epidermis and dermis, as well as hair density in the scalp region. Polynucleotides also possesses strong hydrophilic properties that act as magnets for water molecules, encouraging them to bind to and hydrate the skin. In all, the Nucleofill range can help restore some of the key characteristics of a youthful appearance that are otherwise lost with age.

Nucleofill 20 highlights:

  • Premium-quality, sterile, pyrogen-free regenerative product with 2% polynucleotides per 1.5ml
  • pH between 6.8 – 7.2; viscosity 28-43 pa*s
  • Indicated for application in the face or alternatively, the scalp region
  • Suitable for all skin types and age-related conditions, it fights oxidative stress and targets wrinkles, hyperpigmentation and atrophic scars
  • Water-biding properties of polynucleotides promote iso-osmotic hydration of the skin in the long term
  • Restores youthful soft tissue turgor, density and volume in the skin – working at both deeper and more superficial levels to ‘lift’ lax, aged skin
  • Improves follicle trophism; can be used for a variety of hair-related conditions on the scalp and brows
  • In the face, it presents an an alternative to dermal fillers without risk of lumping or distortion
  • In the scalp, it can help to boost hair density without the need for more extensive treatment preparation (as with PRP)
  • Alternative use: stretch marks on the body and natural improvement of indented scars
  • Convenient pre-filled product: 1.5ml covers one full treatment
  • Notes:

    Administration – hair treatment:

    1. Superficial mesotherapy micro-applications into the scalp, 0.5ml per point, evenly distributed;
    2. Frequency: 2 sessions, one week apart, followed by 2 sessions two weeks apart
    3. Maintenance: 1 session every 2 months.

    Administration – skin treatment:

    1. Bolus applications into the skin (BAP – bioaesthetic points technique), five points on each side of the face, up to 1.5ml per point;
    2. Frequency: 2-4 sessions spaced two weeks apart
    3. Maintenance: 1 session every 3-6 months.

    One sterile 1.5ml Nucleofill 20 product covers one individual treatment application.

    Results: after the initial treatment and within 5-7 days of application, the skin will look brighter and more rejuvenated. Thereafter, it takes a few weeks for the full effects of the biostimulation process to be realised. This may take longer in the case of Nucleofill hair treatments. The regenerative process continues after the completion of each treatment, ultimately helping to regenerate skin and hair density, with long-lasting improvements visible after a full treatment course is realised.

    Product disclaimer: For information on risks and side effects, read the box’s leaflet insert and ask your doctor or pharmacist. Any advice given acts as a guide only; individual suitability and treatment frequency must be pre-assessed. As body chemistry varies, effectiveness and reactions may also differ. Intended for use by professionals. Do not use on broken skin or in areas of infection. Do not use if hypersensitive to polynucleotides. Consult a qualified practitioner before use in pregnant or breastfeeding women. Store at room temperature. If seal is broken, do not use.

    Additional information

    Weight0.044 kg
    Dimensions18.7 × 7 × 3.3 cm



    2%/1.5ml Polynucleotides


    Enclosed in box

    Shelf Life

    2 years from date of manufacture


    1 box (1.5ml syringe)

    We neither offer nor purport to offer any medical advice on this website, our official social media channels, via our customer service personnel nor via any approved affiliates. We will therefore not assume liability for any third parties (either customers or order recipients) involved either directly or indirectly in the procurement and/or usage of products ordered from this website.

    For any injectable, microneedling and/or topical product: we advise that you conduct a patch test and wait in accordance with manufacturer advice (as per the product's packaging and/or enclosed literature) before proceeding to use it. You must agree not to use any products purchased on this website without taking appropriate measures and precautions against any potential harm that may arise. We assume no liability for the negative consequences of self-use.

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    *Discount applies to first orders; shipping excluded.